.research-main{--muted:var(--ink-2);--line:var(--rule);--wash:var(--badge);padding-top:28px;padding-bottom:64px;overflow-wrap:anywhere}
.research-main h1,.research-main h2,.research-main h3{font-family:'Bricolage Grotesque',system-ui,sans-serif;line-height:1.18;letter-spacing:-.025em}
.research-main h1{font-size:clamp(2.5rem,5vw,4rem);max-width:18ch;margin:18px 0 24px}
.research-main h2{font-size:1.8rem;margin:0 0 16px}.research-main h3{font-size:1.25rem;margin:26px 0 12px}
.research-main p{margin:0 0 18px}.research-main li{margin:0 0 12px}.research-main ul{padding-left:24px}
.research-main a{color:var(--link);text-underline-offset:3px}.research-main small{font-size:.875rem;color:var(--muted)}
.research-main .hero{padding:32px 0 12px}.research-main .hero>p{max-width:66ch;color:var(--muted)}
.research-main .eyebrow{font:500 .75rem/1.6 'JetBrains Mono',monospace;letter-spacing:.05em;text-transform:uppercase;color:var(--muted)}
.research-tabs{display:flex;gap:10px 24px;flex-wrap:wrap;border-bottom:1px solid var(--rule-2);padding-bottom:16px}
.research-tabs a{padding:8px 0;font-weight:700}.research-tabs a[aria-current=page]{color:var(--ink);text-decoration-thickness:3px}
.research-main .banner,.directory-callout{background:var(--wash);padding:22px;border-left:4px solid var(--act);margin:24px 0 32px;font-size:1rem}
.research-main .banner p{margin:10px 0}.directory-callout{border-color:var(--link)}
.research-main button,.research-main input,.research-main select{font:inherit;color:var(--ink);background:var(--raise);border:1px solid var(--line);border-radius:6px;min-height:44px;padding:10px 12px;max-width:100%}
.research-main button{cursor:pointer}.research-main button[aria-pressed=true]{background:var(--wash);outline:2px solid var(--link);outline-offset:-2px}
.research-main :focus-visible{outline:3px solid var(--link);outline-offset:4px}
.quicklinks,.toolbar,.search-controls{display:flex;gap:10px 18px;flex-wrap:wrap;align-items:center;margin:24px 0}
.quicklinks a{padding:6px 0}.search-controls>label:first-child{flex-basis:100%;font-weight:700}.search-controls input[type=search]{flex:1 1 300px;min-width:0}
.canada-filter{display:flex;gap:10px;align-items:center}.research-main input[type=checkbox]{width:22px;height:22px;min-height:22px;flex:none;accent-color:var(--link)}
.research-main .count,.research-main .label{font-size:1rem;color:var(--muted)}
.research-main .treatment,.study-card{background:var(--raise);border:1px solid var(--rule-2);border-radius:12px;padding:28px;margin:24px 0;scroll-margin-top:calc(var(--header-height,90px) + 20px)}
.research-main .card-top{display:flex;gap:12px;justify-content:space-between;align-items:center;flex-wrap:wrap;margin-bottom:18px}
.research-main .scope,.research-main .status{display:inline-block;background:var(--wash);padding:5px 10px;border-radius:4px;font-size:.875rem;line-height:1.5}
.research-main .summary{font-size:1.25rem;max-width:66ch}.research-main .sources,.research-main .footnote{font-size:.875rem;color:var(--muted);line-height:1.65}
.research-main .sources{margin:18px 0}.research-main .footnote{border-top:1px solid var(--rule-2);padding-top:16px;margin-top:18px;margin-bottom:0}
.research-main details{margin:22px 0;padding:16px;background:var(--paper);border-radius:6px}.research-main summary{font-weight:700;cursor:pointer;min-height:44px;align-content:center}.research-main details p{margin-top:16px}
.research-main .trial{display:grid;grid-template-columns:1fr 1.4fr;gap:20px;padding:18px 0;border-bottom:1px solid var(--rule-2)}.research-main .trial p{font-size:1rem;margin:8px 0}
.research-main .next{border-left:3px solid var(--link);padding-left:16px;margin:24px 0}.research-main .next p{font-size:1rem;margin-top:8px}
.research-main .methods{border-top:1px solid var(--rule-2);padding:36px 0;margin-top:40px}
.study-stats{display:flex;flex-wrap:wrap;gap:16px 36px;margin:28px 0}.study-stats b{font-family:'Bricolage Grotesque',sans-serif;font-size:2rem;margin-right:6px}
.study-filters{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:18px;background:var(--sunk);border:1px solid var(--rule-2);border-radius:12px;padding:24px;margin:28px 0}
.study-filters label{display:flex;flex-direction:column;gap:8px;font-size:1rem;font-weight:600;min-width:0}.study-filters label:first-child{grid-column:1/-1}.study-filters .remote-option{flex-direction:row;align-items:center;grid-column:1/3}.study-filters button{align-self:end}
.study-meta{font-size:1rem;color:var(--muted)}.research-main [hidden]{display:none!important}.research-main .table-scroll{overflow:auto}.research-main table{border-collapse:collapse;font-size:1rem}.research-main td,.research-main th{border:1px solid var(--rule);padding:12px;text-align:left;vertical-align:top}
@media(max-width:700px){.research-main{padding-left:18px;padding-right:18px}.research-main .treatment,.study-card{padding:20px}.study-filters{grid-template-columns:1fr;padding:18px}.study-filters .remote-option{grid-column:auto}.research-main .trial{grid-template-columns:1fr;gap:8px}.research-main h2{font-size:1.55rem}.study-stats{gap:10px 24px}}
@media print{header.top,.site-footer,.research-tabs,.toolbar,.search-controls,.quicklinks,.print-hide{display:none!important}.research-main{--paper:#fff;--raise:#fff;--ink:#111;--muted:#333;--rule:#777;--rule-2:#aaa;--link:#123;--wash:#eee;max-width:none;font-size:11pt;padding:0}.research-main .sources{font-size:9pt}.research-main h1{font-size:28pt}.research-main h2{font-size:18pt}.research-main .treatment,.study-card{box-shadow:none}}

/* Research reading scale. Rem units continue to follow A+ and browser zoom. */
.research-main{font-size:1.125rem;line-height:1.7}
.research-main p,.research-main li{font-size:1.125rem;line-height:1.7}
.research-main h2{line-height:1.25}
.research-main h3{line-height:1.35}
.research-main .summary{font-size:1.125rem;line-height:1.7}
.research-main .sources,.research-main .footnote,.research-main small,.research-main .label,.research-main .count,.research-main .study-meta{font-size:1rem;line-height:1.65}
.research-main .trial p,.research-main .next p,.research-main .banner{font-size:1.125rem;line-height:1.7}
.research-main .treatment>p,.research-main .study-card>p,.research-main details p,.research-main details ul{max-width:68ch}
.research-main section[aria-label]{padding-top:0;padding-bottom:0}
.research-main .sources a{display:inline-block;padding:5px 0}
.research-main .research-tabs{display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:10px;border:0;padding-bottom:0}
.research-main .research-tabs a{display:flex;align-items:center;min-height:48px;border:1px solid var(--rule-2);border-radius:6px;padding:10px 14px;font-size:1rem;line-height:1.5;text-decoration:none}
.research-main .research-tabs a[aria-current=page]{background:var(--wash);border-color:var(--link)}
.research-main .study-filters{gap:20px}
.research-main .study-filters label{font-size:1rem;line-height:1.5}
.research-main input,.research-main select,.research-main button{font-size:1.125rem;line-height:1.4;min-height:48px}
.research-main input[type=checkbox]{min-height:24px;width:24px;height:24px}
.research-main summary{font-size:1.0625rem;line-height:1.55;min-height:48px;padding:4px 0}
.research-main .study-stats{font-size:1rem;gap:10px 24px;margin:20px 0}
.research-main .study-stats b{font-size:1.6rem}
.research-main .directory-actions{display:flex;flex-wrap:wrap;gap:12px 24px;align-items:center;margin:20px 0}
.research-main .directory-actions>a{min-height:48px;display:inline-flex;align-items:center}
.research-main .research-button{display:inline-flex;align-items:center;justify-content:center;min-height:48px;padding:10px 16px;background:var(--wash);border:1px solid var(--link);border-radius:6px;font-size:1.0625rem;font-weight:700;text-decoration:none}
.research-main .status{font-size:1rem;line-height:1.5;font-weight:600;padding:5px 10px;border:1px solid;border-radius:6px;box-shadow:none;margin:0;max-width:100%;white-space:normal}
.research-main .status[data-status=recruiting]{color:#185a32;background:#e5f3ea;border-color:#337d4b}
.research-main .status[data-status=upcoming]{color:#204f93;background:#e5efff;border-color:#436fac}
.research-main .status[data-status=ongoing]{color:#583680;background:#f0eafa;border-color:#84679f}
.research-main .status[data-status=verify]{color:#765000;background:#fff1d5;border-color:#9b762e}
.research-main .status[data-status=paused],.research-main .status[data-status=closed]{color:#435269;background:#e9edf3;border-color:#738099}
.research-main .status[data-status=invitation]{color:#185d5b;background:#dff2f1;border-color:#468582}
html[data-theme=dark] .research-main .status[data-status=recruiting]{color:#b9ebcb;background:#173c2b;border-color:#509e6b}
html[data-theme=dark] .research-main .status[data-status=upcoming]{color:#c0d8ff;background:#152e50;border-color:#5a88c6}
html[data-theme=dark] .research-main .status[data-status=ongoing]{color:#e3cdfb;background:#332744;border-color:#a080bf}
html[data-theme=dark] .research-main .status[data-status=verify]{color:#ffe0a6;background:#43321b;border-color:#bd934b}
html[data-theme=dark] .research-main .status[data-status=paused],html[data-theme=dark] .research-main .status[data-status=closed]{color:#d6deeb;background:#29313e;border-color:#8794aa}
html[data-theme=dark] .research-main .status[data-status=invitation]{color:#ace9e5;background:#153d3b;border-color:#609e99}
@media(max-width:700px){
 .research-main .hero{padding:22px 0 0}
 .research-main h1{font-size:2.25rem;line-height:1.15;margin:12px 0 20px}
 .research-main h2{font-size:1.5rem}
 .research-main .banner{padding:18px;margin:20px 0}
 .research-main .treatment,.research-main .study-card{padding:20px;margin:20px 0}
 .research-main .card-top{gap:10px;margin-bottom:14px}
 .research-main .study-filters{padding:18px;margin:20px 0}
 .research-main details{padding:14px;margin:18px 0}
 .research-main .methods{padding:28px 0;margin-top:28px}
 .research-main .footnote{margin-top:16px;padding-top:14px}
 .research-main .research-tabs a{padding:10px 12px}
 .research-main .directory-actions{gap:12px}
}
@media print{.research-main .directory-actions{display:none}.research-main .status{color:#111!important;background:#fff!important;border-color:#555!important}.research-main p,.research-main li{font-size:11pt;line-height:1.5}}

/* Freshness is separate from recruitment; retain text labels in every theme. */
.research-main .review-note{border-left:3px solid var(--link);padding-left:14px;font-size:1rem;line-height:1.65}

/* Reading measure and narrow-screen layout; keep type and controls resizable. */
.research-main p,.research-main ul,.research-main ol{max-width:65ch}
.research-main .treatment>p,.research-main .study-card>p,.research-main details p,.research-main details ul{max-width:65ch}
.research-main .trial{grid-template-columns:minmax(0,1fr) minmax(0,1.4fr)}
.research-main .trial>*,.research-main .research-tabs>a{min-width:0}
.research-main .treatment-jump{margin:20px 0;padding:12px 16px;border:1px solid var(--rule-2)}
.research-main .treatment-jump .quicklinks{margin:12px 0 0;gap:8px 20px}
.research-main .treatment-jump .quicklinks a{display:inline-flex;align-items:center;min-height:48px;padding:8px 0}
.research-main .canada-filter{min-height:48px}
@media screen and (max-width:700px){.research-main .trial{grid-template-columns:minmax(0,1fr)}}
@media screen and (max-width:440px){
 .research-main .research-tabs{grid-template-columns:minmax(0,1fr)}
 .research-main .treatment,.research-main .study-card{padding:16px}
 .research-main details{padding:12px}
 .research-main details details{padding-left:8px;padding-right:8px}
 .research-main ul,.research-main ol{padding-left:1.25em}
 .research-main .study-filters{padding:16px}
}
@media print{.research-main .treatment-jump{display:none}}

/* A short entry point with two large, descriptive destinations. */
.research-landing{max-width:960px}
.research-landing .hero{padding-top:12px}
.research-landing .banner{margin:12px 0 24px;padding:18px}
.research-landing .banner p{margin-bottom:0}
.research-choices{display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:20px;margin:24px 0}
.research-choices .research-choice{display:flex;flex-direction:column;padding:24px;border:1px solid var(--rule-2);border-radius:12px;background:var(--raise);color:var(--ink);text-decoration:none;min-width:0}
.research-choices .research-choice:hover{border-color:var(--link)}
.research-choices h2{font-size:1.5rem;margin-bottom:12px}
.research-choices p{color:var(--muted)}
.research-choices .choice-action{color:var(--link);font-weight:700;text-decoration:underline;text-underline-offset:3px;margin-top:auto}
@media(max-width:700px){.research-choices{grid-template-columns:1fr;gap:16px}.research-choices .research-choice{padding:20px}}

/* Audit refinements: early search and concise notices. */
@media(min-width:701px){.research-main .research-tabs{grid-template-columns:repeat(3,minmax(0,1fr))}}
.research-main .research-notice{padding:16px 18px;margin:18px 0}
.research-main .research-notice>p{margin:8px 0 0}
.research-main .research-notice>details{padding:0;border:0;background:none;margin:8px 0 0}
.research-main .research-notice>details>summary{min-height:44px;font-size:1rem}
.research-main .treatment-types .toolbar{margin:12px 0 0}
.research-main .hero{padding-top:20px}
@media(max-width:700px){.research-main .hero{padding-top:16px}.research-main .hero h1{font-size:2rem;margin:12px 0 16px}.research-main .research-notice{padding:14px 16px}.research-main .search-controls{margin:20px 0}.research-main .study-filters{margin:20px 0}}